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Over the past five decades, the important discovery of 45S5 bioactive glass by Larry Hench and his team has led to a wave of innovation in regenerative medicine. Researchers worldwide have been studying the potential of bioactive glasses (BGs), exploring new compositions with therapeutic ions like strontium, boron, zinc, and magnesium. These ions unlock enhanced capabilities, promoting not only bone regeneration but also preventing infections and stimulating the formation of new blood vessels—a process known as angiogenesis.

Angiogenesis is key to regenerating tissues, healing wounds, and supporting the growth of our bones. We can consider it as a natural construction project within the body, where new blood vessels sprout, migrate, and form essential pathways for nutrients and waste exchange. By developing BGs that release biologically active ions, we are harnessing a smart and impactful approach known as ionic medicine. These ions may be effective by themselves and could eliminate the need for complex biomolecules like growth factors.

As part of my doctorate studies, I have been motivated to explore how these ionic products from silicate-based BGs influence endothelial cell behavior—specifically, their ability to form tubular structures. And the results? quite exciting! It turns out that the unique composition of BGs can boost tube formation significantly in a concentration-dependent manner. Additionally, they may increase the natural production of growth factors by cells that are essential for angiogenesis.

These findings highlight the transformative potential of ionic medicine, where even simple ions can outperform complex biomolecules in therapeutic applications. As research in this field continues, we are approaching significant breakthroughs in regenerative medicine. Bioactive glasses have the potential to play a crucial role in setting new treatments that stimulate the body's natural healing and regenerative abilities.

Marcela Arango Ospina

University of Erlangen Nuremberg / Department of Materials Science / Institute of Biomaterials, Germany

marcela.arango@fau.de

www.linkedin.com/in/marcela-arango-ospina